Pharmacological Action of Generic Xenical
Xenical (Orlistat) is a specific inhibitor of gastrointestinal lipases that has a lasting effect. The active ingredient of the drug is Orlistat. Xenical’s therapeutic effect occurs in the lumen of the stomach and small intestine and lies in the formation of a covalent bond with the active serine site of gastric and pancreatic lipases. Inactivated enzyme loses the ability to split the fat from food.
Unsplit fat is not absorbed. This leads to a reduction of calories entering the body, which in turn leads to a decrease in body weight. Thus, the therapeutic effect of the drug occurs without absorption into the systemic circulation. When you need a reliable remedy for overweight, that has a limited and directed action in the organism, you can always buy Xenical at our online pharmacy.
The facts, based on the amount of fat in the stool, show that the drug’s action begins in 24-48 hours after ingestion. In 48-72 hours after the drug’s cancellation the content of fat driven out from the body usually returns to the level that took place before the start of the therapy. You can order Xenical at our online med store and get a safe and effective means for obesity.
Absorption of Generic Xenical
The volunteers with normal body weight and obesity have minimal systemic exposure of the drug. After oral administration, this weight loss medicine is practically not absorbed from the gastrointestinal tract. In 8 hours after ingestion unchanged Xenical could not be determined in plasma, which means that its concentration in plasma is less than 5 ng/ml.
In general, it was possible to reveal the unchanged Xenical in plasma after therapeutic doses only in rare cases, though its concentration was extremely low. The absence of accumulation signs confirms that the absorption of the drug is minimal.
Distribution of Generic Xenical
Xenical has a very low systemic absorption. Binding with plasma proteins (mainly with albumin and lipoproteins) in vitro is 99%. In minimal amounts Orlistat can penetrate into erythrocytes. According to the data, obtained in experimental studies on animals, the metabolism of Xenical occurs mainly in the intestinal wall.
Extirpation of Generic Xenical
Studies in patients with normal weight and overweight showed that 97% of the dose of Orlistat is excreted in the feces, 83% of which remains in an unchanged form. The cumulative renal excretion of substances structurally related to Xenical is less than 2% of the dose. The period of the complete removal of Orlistat from the body (with feces and urine) is 3-5 days. Orlistat and its metabolites can be excreted in the bile. The elimination ways of Xenical in volunteers with normal weight and overweight were similar.
Dosage of Generic Xenical
For adults, the recommended dose of the drug is 120 mg (1 capsule) 3 times a day with each main meal (with food or no later than one hour after a meal). If you miss a meal or the meal contains no fat, the receipt of the medication can also be missed.
The dose increase over the recommended (120 mg 3 times a day) does not enhance its therapeutic effect. The elderly patients, patients with impaired hepatic or renal function do not require the dose adjustment. You can buy Xenical at our online pharmacy whenever you decided to use it.
Generic Xenical Indications
Our generic drug is primarily indicated for:
- Long-term treatment of obesity, or patients with overweight, including those who have risk factors associated with obesity together with a diet;
Special instructions for Generic Xenical
Xenical is effective in long-term weight management programs (weight loss and its long-term maintenance to a new level, the prevention of the repeating weight gain).
The effectiveness of the preparation appears in the improvement of risk factors profile and diseases related to obesity (such as high cholesterol, type 2 diabetes mellitus, impaired glucose tolerance, hyperinsulinemia, hypertension) and in the reduction of the visceral fat amount.
In combination with hypoglycemic drugs such as metformin, sulfonylureas and/or insulin in patients with type 2 diabetes with overweight (BMI ≥ 28 kg/m2) or obese (BMI ≥ 30 kg/m2) Xenical, applied with moderate calorie diet, provides additional improvement of carbohydrate metabolism compensation.
In clinical studies, for the majority of patients treated with Xenical for two full years, the concentration of vitamin A, D, E and K were within normal limits. When you need a reliable remedy for obesity, you can order Xenical at our online med store.
Polyvitamins can be prescribed to ensure a sufficient supply of all needed for the organism nutrients. They should be taken at least 2 hours after taking Xenical or at bedtime.
A patient should keep a balanced, moderately hypocaloric diet that contains no more than 30% of daily calories as fat. It is recommended to consume food containing plenty of vegetables and fruits. The daily intake of fat, carbohydrate and protein should be distributed on three main receptions.
The possibility of adverse reactions from the gastrointestinal tract may increase if this medication is taken on the background of the diet, rich in fats (2000 kcal/day, of which more than 30% - in the form of fat, equivalent to 67g of fat). The daily intake of fat should be distributed on three main receptions.
Weight loss associated with the use of Xenical results in improved glucose metabolism in type 2 diabetes, which may allow or require lower doses of hypoglycemic agents. When you have consulted with your doctor and received his approval, you can buy Xenical at our online med store.
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