More facts about Generic Avalide (Irbesartan + Hydrochlorothiazide 150/12.5 mg):
Generic Avalide (Irbesartan + Hydrochlorothiazide 150/12.5 mg) guide:
Generic Avalide (Irbesartan with Hydrochlorothiazide) is a medication that is primarily used to treat high blood pressure but can be used for other purposes that require the widening of the blood vessels such as congestive heart failure and others. The active substances the drug is based on are called Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin II receptor antagonist and Hydrochlorothiazide is a diuretic.
When should Generic Avalide be used?
The medication is used for the management of blood pressure in various types of hypertension and other heart-related diseases. Avalide can be also used as a part of combined therapy for the management of nephropathy that accompanies arterial hypertension or type 2 diabetes mellitus.
Before you buy Generic Avalide (Irbesartan plus Hydrochlorothiazide), make sure to consult your doctor whether the drug is suitable in your condition.
What is the mechanism of action of Avalide (Irbesartan + Hydrochlorothiazide)?
Avalide and its generic versions are made of two synergic-acting components - Irbesartan and Hydrochlorothiazide. Irbesartan is an angiotensin II receptor antagonist that prevents the blood vessels narrowing caused by the natural substance angiotensin II. The drug promotes the decrease of the peripheral resistance of the blood vessels, causes an increase in glomerular filtration rate and renal blood flow, as well as affects plasma renin activity.
Other blood pressure medications that are included in the class of angiotensin-converting enzyme inhibitors affect the metabolism of bradykinin (a natural peptide that promotes blood vessels extension), but Generic Avalide (Irbesartan and Hydrochlorothiazide) does not affect it or other peptides. This is one of the reasons why the medication is better tolerated than the other group of the hypotensive drugs.
The other component of the medication, Hydrochlorothiazide, is a thiazide diuretic that prevents accumulation of salts in the body which in its turn can result in swelling.
How to use Generic Avalide?
In this section we are going to give you the general recommendations for the medication use but we advise you to consult your doctor and get individual instructions from him or her before you buy Generic Avalide (Irbesartan and Hydrochlorothiazide) to protect yourself from any negative effects of the medication.
The pills are taken orally without chewing and are washed down with sufficient amount of water. The regular dosage for patients without any other chronic conditions is 150 mg a day taken in one intake regardless of meal time. This dosage is optimal for stable blood pressure reduction for 24 hours. However, in individual cases, especially in patients over 75 years of age or those who are getting hemodialysis, the dosage adjustment may be required. For these groups of patients the recommended initial dosage is 75 mg a day.
In people with known arterial hypertension or type 2 diabetes, the treatment should be started with the dose of 150 mg per day and gradually increased to 300 mg a day. The dosage of 300 mg a day is the preferred maintenance dose for the treatment of nephropathy.
In patients with water-electrolyte imbalance, before the start of the treatment, a restoration of the volume of circulating blood or elimination of hyponatraemia is required.
People with impaired kidney function do not require the dosage regimen adjustment. In visible violations of normal liver functions of mild or moderate severity, the dosage also doesn’t require adjustments.
For patients on hemodialysis during the treatment, the initial dose in most cases is 75 mg per day.
The safety as well as effectiveness of the drug in patients under the age of 18 years have not been studied sufficiently yet.
Whom the drug is contraindicated?
It is not advised to buy Generic Avalide (Irbesartan + Hydrochlorothiazide) and use the medication if you are pregnant, breastfeeding, in children below 18 years of age, in lactose intolerant patients, in patients with glucose-galactose malabsorption, and in hypersensitivity or allergy to one or several components of the drug.
The drug should be used with caution in patients with stenosis of mitral or aortic valves, obstructive hypertrophic cardiomyopathy, severe dehydration of the body, hyponatremia, diarrhea, diet with low salt intake, severe kidney or liver failure, kidney transplant, during hemodialysis, unilateral stenosis of the artery of a single functioning kidney, bilateral stenosis of the kidneys arteries, chronic heart failure of the III-IV functional class, cardiac ischemia, atherosclerosis of the blood vessels of the brain, and in patients over 75 years of age.
What side effects can Avalide cause?
In rare cases, Avalide or Generic Irbesartan use result in a condition in which breakdown of skeletal muscle tissue and subsequent kidney failure may occur. The typical symptoms of this condition are muscle pain, fever, weakness, nausea or vomiting, and dark colored urine.
Other possible adverse reactions include headaches, dizziness, central nervous system functions violations, hyperemia of the skin surface, tachycardia, coughing, dyspepsia (indigestion), heartburn, taste changes, hepatitis and other disorders of the digestive system, erectile dysfunction, severe kidney function impairment, chest pains, rash, angioedema, seizures, extremely lowered or elevated blood pressure, and hyperkalemia.
If you experience any of these or other symptoms after the pill intake, call your doctor immediately and stop using the drug if necessary.
With what medications Generic Irbesartan should not be combined?
If you have diabetes, do not use the medication at the same time with any medication that contains aliskiren.
The drug contains a diuretic therefore it is not advised to combine it with other diuretics. It also advised to refrain from drinking alcohol.
Your doctor can think that the medication is also incompatible with other drugs or supplements you use. You should inform him or her about all preparations that you use before you buy Generic Avalide (Irbesartan and Hydrochlorothiazide) and start using it.
What should you do in the overdose with Avalide?
The overdose symptoms with Avalide are dizziness, fast or slow heartbeat, loss of consciousness, and others as a result of extremely lowered arterial pressure. The treatment consists of symptoms relief and monitoring of the vital functions by the doctor.
Is there a difference between the brand-name drug and the generic?
The drugs are identical by the composition and effect. They are made by different drug makers who are obliged to register new names for their drugs. The drug makers also are free to set significantly different prices for the same medications which is why you can buy Generic Avalide (Irbesartan + Hydrochlorothiazide) made by the less-advertised manufacturer numerous times cheaper than the brand-name medication.
Where it is better buy Avalide (Irbesartan)?
The drug should be taken for long periods of time. Therefore, it is reasonable to buy it from an online drugstore like ours that sells the same drugs as your local pharmacies but cheaper. We also do not ask you for a prescription because according to the laws of the countries where we ship our products from they are sold over-the-counter. In such a way, you can save both on visits to your doctor and the drug itself without compromising your therapy quality.
Avalide (Irbesartan) shipping by Rxshop
We have two shipping options: standard and express. Naturally, standard shipping is cheaper but it takes up to 25 days in some countries. We ship to the U.S. and other countries without an exception. All parcels come with the tracking numbers you get to your email once the parcel is packed and registered at the post office. You can find out more about our shipping and returns policy in the FAQ section of our pharmacy’s website.
Our doctor prescribes Irbesartan + Hydrochlorothiazide online for free, and there is no doctor’s consultation fee.
All orders of Irbesartan + Hydrochlorothiazide arrive in discrete unmarked parcels. We leave the shipment description blank.