More facts about Generic Precose (Acarbose 50 mg):
Generic Precose (Acarbose 50 mg) guide:
What it the medication that is sold under the brand name Precose?
The medication you can buy as Precose is also sold under a variety of different trade names. The reason for that is that the active substance on which this medication is based, Acarbose, was developed many years ago and now the chemical formula is publicly known and can be used virtually by any drug-manufacturing company. This means that if your doctor appoints you to buy Precose for diabetes II treatment, you can purchase the same medication made by another company for the lower price as usually the medications with less-known names are cheaper.
The medication is a hypoglycemic agent that competitively and reversibly inhibits pancreatic alpha-amylase (hydrolyses polysaccharides to oligosaccharides) and intestinal membrane-bound alpha-glucosidases (splits oligo-, tri- and disaccharides to glucose and other monosaccharides) in the lumen of the small intestine. Through this, it reduces the formation and absorption of glucose in the intestine, reduces postprandial hyperglycemia, and daily fluctuations in blood glucose. The distinguishing feature of this agent is that it does not increase the incretion of insulin and does not cause hypoglycemia, i.e. the lowering of the blood sugar below norm. It provides an equal effect on the balanced absorption of the glucose from the intestines and its average concentration and fluctuations during the day are lowered. Besides, if the level of glycosylated hemoglobin rises, Acarbose also reduces its level.
Nearly 35% of the administered dose is absorbed in the form of metabolites and only 2% in an active form. The medication is metabolized in the gastrointestinal tract, mainly by the intestinal bacteria and partially by the digestive enzymes with the resulting formation of over 13 compounds of sulfate, methyl and glucuronic conjugates. After the intake of the pills, there are two peak concentration moments in the blood plasma that occur within one hour and within 5-7 hours. It is considered that the second peak is associated with the absorption of products of bacterial decay from the deep sections of the small intestine.
The bioavailability, i.e. the amount of the drug active within the body is only 1-2% of the consumed dosage though it is considered the most desirable one as the active agent acts locally in the small intestine. This low bioavailability doesn’t influence the effeteness of the medication.
The preparation is washed out of the body in the feces (about 51%), and 34% in a form of metabolites in the urine.
Can you replace the branded medication with its generic analog?
As we have previously stated, there are a number of medicines made utilizing the same chemical formula as the branded medication Precose has. These medications are made by different companies and are named differently too as their makers cannot use the copyrighted name. They are usually cheaper than the branded medications because their producers do not invest in promotions of their products as the owners of large brand do. You can find such medications if you opt to buy Generic Precose. It is a common name used by people who know the brand name under which the medication is known but do not know the other trade names. It is easy to find the generic as all pharmacists and doctors know exactly what you mean when you ask for this medication. The cheapest way, however, to get the drug is to order it online. But make sure to check the dosage of the active substance and its name before you place an order to be sure that you will receive the right medication. Besides, we advise you to opt only for reliable online medstores who have positive reviews not only on their own websites but also on the third-party sources.
When can you buy Precose?
The indication for the pills use is diabetes type II, but if you have this diagnosis, it doesn’t mean that you need namely this medication. It is important to undergo a comprehensive checkup and get a consultation with a specialist who will choose you a complete course of therapy and regimen of meals intake and exercise. Usually, doctors prescribe to buy Acarbose after a patient followed a special diet for at least 6 months and no significant improvement of the condition is observed. Besides, the medication can be appointed in the insufficient or complete inefficiency of sulfonylureas along with a low-calorie diet.
The medication can be also used as a part of a combination therapy of diabetes type I, and as a prophylaxis of diabetes type II in people with lowered glucose tolerance along with curative diet and exercising.
When cannot you buy Acarbose?
Even if you are diagnosed with one of the above-listed conditions, Acarbose-based medications can be contraindicated for you under a condition if you are allergic to this particular drug, suffer from diabetic ketoacidosis, liver cirrhosis, acute and chronic inflammatory bowel diseases, complicated digestion and absorption disorders (including malabsorption syndrome, maldigestia syndrome), Remkheld's syndrome, pathology of the gastrointestinal tract with increased flatulence, ulcerative colitis, intestinal obstruction, or predisposition to it, stricture and ulcers of the intestine, hernias of large size, and/or severe chronic renal failure.
Besides, it is also contraindicated to buy Generic Acarbose for the use in pregnant and breastfeeding women.
Restrictions on the use, i.e. when the medication is not advised to be used or should be used cautiously: fever, infections, injuries, surgical interventions, and age less than 18 years (safety and efficacy not determined).
What interactions with other medicines should you avoid when you use Precose?
If the medication is appointed to be used along with insulin or medications that contain sulfonylureas or metformin, the level of glucose can lower to the level of hypoglycemia and coma can develop. Therefore, the concurrent use of these preparations requires responsible approach and dosage adjusted by a doctor.
The mediation can influence the bioavailability of digoxin which will require the dosage adjustments of the later.
It is not recommended to take the pills along with Cholestyramine, intestinal sorbents, and enzyme preparations as they can lower the effect of Precose or its generic.
Diuretics, corticosteroids, phenothiazines, thyroid hormones, estrogens, incl. in the composition of oral contraceptives, phenytoin, nicotinic acid, sympathomimetics, calcium antagonists, isoniazid and other agents that cause hyperglycemia significantly weaken specific activity of the drug and can cause possible decompensation of diabetes mellitus.
Inform your doctor when you order Precose and plan to use it if you already take any other pills, mixtures, and so on.
Adverse effects that can be caused by the use of Generic Precose
The use of the medication can cause such unpleasant symptoms as pain in the belly, bloating, nausea, diarrhea, intestinal obstruction, jaundice, hepatitis, skin rash, hyperemia, exanthema, urticaria, swelling, and others.
Consult your healthcare provider how to reduce these symptoms and in case of which ones you should discontinue using the drug.
How to use Generic Acarbose?
The optimal dosage is selected individually for every patient as the efficiency and tolerance of the medication can greatly vary. In this guide, we provide the general recommendations for use but you must consult your doctor before you order Generic Precose if you decided to start the therapy without your doctor indications.
The pills are taken entirely without chewing with a small amount of water before a meal or chewed with the first portion of food. The treatment course length can be continuous.
The recommendations for combined therapy of diabetes along with a diet:
The initial dosage is one pill by 50 mg taken three times a day or a half of 100 mg pill taken three times a day. If necessary, the dosage can be heightened to 100 mg taken three times a day. In some cases, the daily dosage can be increased to 200 mg taken three times a day.
It is recommended to raise the dosage four-eight weeks after the therapy started if the effect of the medication use during this time was insufficient. If a patient follows a diet and still claims worsening of the condition, the further rise of the dosage must be stopped and the currently taken dose should be sometimes even lowered. The average well-tolerable dosage is 300 mg a day (100 mg taken three times before main meals).
Prophylaxis of diabetes type II in patients with a violation of glucose tolerance in combination with diet and exercise:
The recommended dose for treatment of type II diabetes in patients with impaired glucose tolerance is 100 mg three times a day before meals.
The initial dose is 50 mg once a day (1 tablet of 50 mg or a half of 100 mg tablet once a day). Within 3 months, the dose is increased to 100 mg 3 times a day (2 tablets 50 mg 3 times daily or 1 tablet 100 mg 3 times daily).
Patients of advanced age (over 65 years) do not require dose adjustment.
Patients with hepatic insufficiency do not require dose adjustment.
Overdose of Generic Acarbose
An overdose of the medication along with the food or drinks that contain carbohydrates can lead to flatulence and diarrhea. In case you developed these symptoms, it is advised to exclude the consumption of carbohydrates for four-six hours.
In case you overdosed without eating food reach in carbohydrates, the likelihood of adverse effects is minimal.
If you develop any other adverse reactions, seek medical help.
Where to buy Precose cheap?
The therapy requires the long-time use of the medication and it’s natural that people seek for cheaper alternatives to the branded medication. We offer you to order Acarbose made by a reputable generic-making company Glenmark Pharmaceuticals or Bayer Pharmaceuticals at the adequate prices. We guarantee the highest quality of the medications we sell.
Shipping of Precose
We ship all medications sold at our online med store internationally offering both standard and express shipping.
Our doctor prescribes Acarbose online for free, and there is no doctor’s consultation fee.
All orders of Acarbose arrive in discrete unmarked parcels. We leave the shipment description blank.