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What is Vagifem? How to Treat with Generic Estradiol.

Drug description:
Generic Vagifem is exactly the same medication as the branded drug Vagifem. It is based on the hormone estradiol used mostly for the coping of estrogen deficiency consequences in women in menopause and after the menopause was medically induced (for instance, after removal of ovaries due to cancer). The pills are used intra-vaginally although there are other forms of the medications based on estradiol taken orally. These vaginal pills are used mainly to cope with the local symptoms such as dryness, discomfort, burning, and itching of the vagina.
Brand name:
Generic name:
Helps to cope with the local negative symptoms of estrogen deficiency in menopause and various medical conditions.
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Vagifem (Estradiol 25 mcg)
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More facts about Generic Vagifem (Estradiol 25 mcg):

Generic Vagifem (Estradiol 25 mcg) guide:

What is the preparation marketed as Vagifem?

Vagifem is a registered trademark of Novo Nordisk Health Care AG, an American-based pharmaceutical company. The medication is based on the most active female hormone, Estradiol and is applied locally.

The estrogens that come from within the body are needed by the women after the menopause because their production in this age is diminished. It contributes to a number of conditions developments such as osteoporosis, dryness, and irritability of the vagina, genitourinary tract infections, and so on. Therefore, doctors commonly prescribe either oral estrogens or local, vaginal inserts such as Vagifem based on the symptoms.

The active substance of the medication is no longer protected by the patent and can be used by various pharmaceutical companies which make it possible for you to choose whether to buy Vagifem which is an advertised and expensive medication or its analog with the same effect and composition but sold cheaper.

The hormone has a number of positive effects on the female body such as promotes timely rejection of the endometrium and regular bleeding, increases concentrations in the blood of thyroxin, iron, copper, etc ., has a procoagulant effect, increases the synthesis in the liver of vitamin K-dependent clotting factors, renders anti-atherosclerotic activity, increases the content of high density lipoproteins and lowers the level of low density lipoproteins (“bad” cholesterol), modulates receptors for progesterone and sympathetic regulation of smooth muscle tone, causes intravascular fluid to enter the tissues and compensatory retention of sodium and water, and so on. However, there are downsides to the long-term therapy with the medication that should be taken into account before you buy Generic Vagifem. For instance, the long-term use of estrogens only in women of the climacteric period can cause the endometrial hyperplasia and increases the risk of endometrial cancer. To minimize the risk, it is advised to combine the medication use with progestogen hormones (usually, for 10-12 days a month) which promotes the transition of the mucous membrane of the uterus into the secretory phase with its rejection and subsequent menstrual-like bleeding after the discontinuation of the administration of progestogen.

Besides, women who are in post menopause and use the medications based on estradiol has a higher chance of developing breast cancer which is why it is important to weigh all the risks and discuss them with your gynecologist before you decide on the medication use.

What is Generic Vagifem, is it different from the branded medication?

The medications you can find looking for Generic Vagifem ideally would need to be all identical to the branded medication because such practice is promoted by the World Health Organization to make all medications available worldwide and affordable to everyone. However, it is not always so. For instance, some sellers offer the medication with the same composition but in a different formulation, i.e. in oral pills. At our online pharmacy, you can find various forms of Estradiol (the component of Vagifem that is responsible for the preparation’s effect). But please before you buy Estradiol, make sure that you clarify with your doctor what formulation and dosages are needed for you and then consult our pharmacists about whether we sell the right medication for you or not.

When should I buy Estradiol?

We strongly advise you to consult your doctor before you buy Generic Estradiol of any form as the irresponsible or incorrect use of the hormone can be very dangerous to your health. Besides, it is not recommended to start the hormonal therapy before you undergo regular medical examinations for at least one year.

Various forms and dosages of this medication are used to treat estrogenic insufficiency in menopause and in surgical menopause, incl. after ovariectomy or radial castration, primary and secondary amenorrhea, hypomenorrhea, oligomenorrhea, dysmenorrhea, secondary estrogen insufficiency, baldness associated with hyperandrogenism, excessive body hair due to hormonal imbalance, vaginitis, underdeveloped genitals, infertility, weak uterus function during labor, to suppress the production of breast milk after a miscarriage or when a woman decides not to breastfeed, and so on.

The vaginal tablets are used for the vulvar and vaginal atrophy due to menopause, or vaginitis manifested in the dryness of the vagina, burning or itching sensation, and so on.

When shouldn’t I buy Estradiol-based medications?

The hormone is contraindicated to be used in hypersensitivity to it, any estrogen-depended tumors, sickle-cell anemia, herpes, otosclerosis, gallbladder diseases, unusual vaginal bleedings, severe liver conditions, thrombosis or predisposition to it, moderate to severe heart or vascular conditions, and others.

Besides, the hormone is not encouraged to be prescribed for women who suffer from diabetes, migraines, epileptic seizures, kidney failure, any liver conditions, swelling, fibrocystic mastopathy, porphyria, pituitary tumors, diffuse connective tissue diseases, Dubin-Johnson syndrome or Rotor syndrome, and others.

What possible adverse effects can be provoked by Vagifem use?

There is a wide range of adverse effects that can be caused by the use of estradiol-based medications. Some of them do not require the discontinuation of the therapy while others are dangerous and require the immediate stop of the medication use and notification of your doctor.

The adverse effects that can be caused by Vagifem use include dizziness, headache, migraine, depression, chorea, nausea, vomiting, pain in the stomach, bloating, diarrhea, anorexia, yellowing of the skin, pancreatitis, liver function impairment, uterine bleeding of unclear etiology, change in the character of uterine bleeding, irregular menstruations, elevation of arterial pressure, spasms of the calf muscles; in long-term application can develop the infringement of an balance of sodium, calcium and water with formation of peripheric edemas (swelling), lump in breast, and others.

No matter what adverse effects you suffer from when you order Vagifem and start using it, make sure to inform your gynecologist right away about them.

Interaction of Vagifem with other medications

The preparation can lower the action of medications that enhance diuresis, medicines used to treat high arterial pressure, hypoglycemic agents, and anticoagulants.

While you use the hormone-based medication, you may need to ask your doctor to adjust the dosages of hypoglycemic medications if you use them.

The preparation use enhances the effect of lipid-lowering drugs.

The effectiveness of the preparation can be reduced by some anti-seizure medications, antibacterial medications and antibiotics, and others.

The effect of the medication is enhanced with the use of folic acid and thyroid medications.

The intake of alcohol can increase the concentration of the hormone in the body and enhance its adverse reactions.

How to use Generic Vagifem?

When you order Generic Vagifem you need to check that you get the same formulation, i.e. vaginal pills, and dosage per pill corresponds to the dosage of estradiol appointed to you by your doctor.

The branded vaginal pills are used by one 10 mcg pill a day inserted into the vagina for the first week of the therapy. Then, the dosage is reduced to two pills a week. In case you missed the pills, you should apply it as soon as you remembered but skip the missed dosage if it’s time for the next application already. The therapy duration is appointed by the doctor. Besides, it is not safe to use estradiol alone as it can contribute to cancer development so you must ask your doctor and follow his or her instructions on the use of accompanying medications.

The complete instruction how to properly insert the pills is included in the box of pills that you receive when you purchase the medication from our online pharmacy.

If you order another formulation instead of Vagifem, you need to inform your doctor that you purchased Estradiol in another formulation, i.e. oral tablets and ask him or her whether this medication would be suitable for you.

Overdose of the medication

The overdose is manifested in nausea, vomiting, and in some cases, abnormal vaginal bleeding. It is treated with the discontinuation of the therapy and symptomatic treatment aimed to lower the negative symptoms.

Where to buy Vagifem?

The branded medication is sold at virtually any drugstore in the U.S. and the Western Europe but if you want to get the same medication cheaper, you can order Estradiol from our online pharmacy but make sure to order the correct formulation (our pharmacists will help you find and order the right one).

Vagifem shipping

Rxshop med store specializes in international selling of the medications and therefore ships all drugs worldwide.

Free prescription

Our doctor prescribes Estradiol online for free, and there is no doctor’s consultation fee.

Discrete packaging

All orders of Estradiol arrive in discrete unmarked parcels. We leave the shipment description blank.

For more answers see the FAQ section
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