Buy Exelon (Rivastigmine) Online — Dual AChE/BuChE Cholinesterase Inhibitor for Alzheimer's & Parkinson's Disease Dementia (Capsules & Patch)
Exelon is the original brand-name formulation of Rivastigmine — a dual cholinesterase inhibitor uniquely distinguished as the only medication FDA-approved for BOTH Alzheimer's disease dementia AND Parkinson's disease dementia. Developed by Novartis and FDA-approved since 2000 (oral) and 2007 (transdermal patch), Exelon offers two distinct formulations: traditional oral capsules and the innovative Exelon Patch, which bypasses the GI tract to provide significantly better tolerability.
The active ingredient is Rivastigmine Tartrate, a carbamate-based pseudo-irreversible cholinesterase inhibitor that uniquely inhibits BOTH acetylcholinesterase (AChE) AND butyrylcholinesterase (BuChE). This dual inhibition may provide additional benefit as Alzheimer's progresses — BuChE levels increase as AChE decreases in advanced disease. Rivastigmine has a short plasma half-life (~1-2 hours) but the carbamate-enzyme bond persists for ~10 hours, providing extended pharmacodynamic effect.
Exelon is FDA-approved for mild-to-moderate Alzheimer's disease and mild-to-moderate Parkinson's disease dementia — the unique dual-approval makes Exelon the preferred cholinesterase inhibitor when Parkinson's dementia is present. Off-label uses include Lewy body dementia (strong evidence), vascular dementia, traumatic brain injury cognitive complaints, and Down syndrome cognitive decline.
The medication is available as Exelon 1.5, 3, 4.5, and 6 mg capsules, 2 mg/mL oral solution, and Exelon Patch transdermal in 4.6, 9.5, and 13.3 mg/24h strengths. Oral capsule dosing: start 1.5 mg twice daily with food, increase by 1.5 mg BID every 2 weeks to target 3-6 mg BID. Patch dosing: start 4.6 mg/24h, increase to 9.5 mg/24h after 4 weeks (most common maintenance).
Critical safety considerations include significant GI side effects with oral capsules (nausea, vomiting, diarrhea, anorexia, weight loss — much less with patch), cardiac conduction effects (bradycardia, syncope), tremor (especially concerning in Parkinson's patients), skin reactions at patch sites (rotate sites), rare hallucinations, very rare seizures, and the standard cholinesterase inhibitor warning against concurrent anticholinergic medications.
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- Mild Alzheimer Disease: FDA-approved for mild Alzheimer's (MMSE 21-26) — first-line cholinesterase inhibitor;
- Moderate Alzheimer Disease: FDA-approved for moderate Alzheimer's (MMSE 10-20);
- Parkinson Disease Dementia (PDD): FDA-approved for Parkinson's disease dementia — ONLY cholinesterase inhibitor with this approval (signature unique indication);
- Mild Parkinson Dementia: FDA-approved for mild Parkinson's disease dementia;
- Moderate Parkinson Dementia: FDA-approved for moderate Parkinson's disease dementia;
- Lewy Body Dementia (LBD): Off-label for Lewy body dementia — strongest clinical evidence among cholinesterase inhibitors;
- DLB Dementia Lewy Bodies: For dementia with Lewy bodies (DLB) variant;
- Vascular Dementia: Off-label for vascular dementia — modest evidence;
- Mixed Dementia: Off-label for mixed Alzheimer's and vascular dementia;
- GI Intolerant Patients: Exelon Patch preferred for patients intolerant of oral cholinesterase GI effects;
- Swallowing Difficulties: Exelon Patch or oral solution for patients with swallowing difficulties;
- Adherence Challenged Patient: Once-daily Exelon Patch supports adherence with caregiver visible verification;
- Combination With Memantine: Standard combination with Memantine in moderate-to-severe Alzheimer's for synergistic benefit;
- Late Stage Alzheimer Dual Mechanism: Dual AChE/BuChE inhibition may benefit later disease stages when BuChE predominates;
- Switch From Donepezil: Alternative for patients with inadequate response to Donepezil;
- Switch From Galantamine: Alternative for patients intolerant of Galantamine;
- Post TBI Memory Complaints: Off-label for memory complaints following traumatic brain injury;
- Down Syndrome Cognitive Decline: Off-label for cognitive decline in adults with Down syndrome;
- Long Term Dementia Maintenance: Suitable for long-term maintenance therapy throughout disease progression.
- Better Attention: Improvement in attention and concentration through enhanced acetylcholine signaling;
- Better Cognitive Function: Overall cognitive improvement on standardized assessments (ADAS-cog, MMSE);
- Less Cognitive Decline: Slows progression of cognitive decline in Alzheimer's and Parkinson's disease dementia;
- Better Daily Function: Improvement in activities of daily living (dressing, eating, personal hygiene);
- Better Executive Function: Improvement in planning, organization, and problem-solving abilities;
- Less Confusion: Reduction in episodes of confusion and disorientation;
- Better Orientation: Improved orientation to time, place, and person;
- Less Hallucinations PDD: Reduction in visual hallucinations characteristic of Parkinson's disease dementia and Lewy body dementia;
- Better Visual Recognition: Improvement in visual perception and recognition in Lewy body dementia;
- Better Engagement: Increased engagement with family members and surroundings;
- Less Apathy: Improvement in apathy and motivation;
- Better Parkinson Dementia Cognition: Unique FDA-approved cognitive benefit specifically in Parkinson's disease dementia;
- Better Combination Therapy Response: Synergistic benefit when combined with Memantine in moderate-to-severe Alzheimer's;
- Better Late-Stage Benefit: Dual AChE/BuChE inhibition may provide continued benefit as disease progresses;
- Better Caregiver Reports: Caregiver-reported improvement in patient function and behavior;
- Better Quality of Life: Substantial improvement in patient and caregiver quality of life;
- Less Hospitalization: Effective dementia therapy reduces hospitalizations and nursing home placement;
- Better Patch Tolerability: Exelon Patch significantly reduces nausea, vomiting, diarrhea vs oral capsules;
- Better Patch Adherence: Once-daily patch application with caregiver-visible verification of dosing;
- Smoother Drug Levels Patch: Transdermal delivery provides smoother blood levels than oral peaks;
- Brand Exelon: Original Novartis brand of Rivastigmine with established global clinical reputation since 2000;
- Generic Rivastigmine: Affordable generic versions expand global access to dual cholinesterase inhibitor therapy;
- Exelon Patch Transdermal: Transdermal patch formulation bypasses GI tract for significantly better tolerability;
- Exelon Capsules Oral: Traditional oral capsules in 1.5-6 mg strengths for twice-daily dosing;
- Exelon Oral Solution: 2 mg/mL liquid formulation for patients with swallowing difficulties;
- Cholinesterase Inhibitor: Foundational cholinesterase inhibitor class for dementia therapy;
- Dual Cholinesterase Inhibitor: Unique dual AChE/BuChE inhibition — distinct from Donepezil and Galantamine;
- Carbamate Pseudo Irreversible Inhibitor: Carbamate-based pseudo-irreversible binding provides extended pharmacodynamic effect;
- AChE Plus BuChE Dual: Dual enzyme inhibition may provide additional benefit as Alzheimer's progresses;
- Alzheimer Plus Parkinson Dementia: ONLY cholinesterase inhibitor FDA-approved for BOTH conditions — signature unique distinction;
- Parkinson Dementia Standard: Standard therapy for Parkinson's disease dementia per clinical guidelines;
- Lewy Body Dementia Standard: Standard off-label therapy for Lewy body dementia with strongest evidence;
- Combination Therapy Standard: Standard combination partner with Memantine in moderate-to-severe disease;
- Multiple Formulations Patient Choice: Three formulations (capsules, solution, patch) support individualized patient needs;
- WHO Essential Medicine: Listed on the WHO Model List of Essential Medicines for dementia care;
- 25 Plus Year Clinical History: Extensive real-world safety and efficacy data since 2000 across millions of patient courses.
Generic Exelon (Rivastigmine 1.5 mg) Medication guide:
Exelon pills – what are they?
Exelon is one of the trade names of the medication substance Rivastigmine that was developed and patented in the early 1990s. Nowadays it is sold under a variety of trade names because the formula isn’t protected by the patent anymore. It means that basically any pharmaceutical company can make the drugs with the same formula as Exelon but they have to name their products differently. Fortunately, you can easily obtain a cheaper version of the medication without even knowing its other trade names if you buy Generic Exelon. This is a standard name used by sellers, pharmacists, and doctors to talk about the other versions of the medications which are sold under other names but have the same composition as the brand-name drug which name is contained in this “code” name.
The active substance of the medication Exelon and its generics is an acetylcholinesterase inhibitor used in the treatment of Alzheimer's disease and dementia in Parkinson's disease. Read further to know when exactly the medication is prescribed and how does it render its effect.
What is the principle of action of Exelon?
The active substance of the preparation marketed under the brand name Exelon is a selective inhibitor of acetylcholinesterase of the brain of the carbamate type. It is considered that it promotes the cholinergic transmission, slowing down the degradation of acetylcholine released from cholinergic neurons with unbroken function. It selectively raises the level of acetylcholine in the cerebral cortex and hippocampus. Thus, it improves the cognitive function impaired due to the failed cholinergic transmission that is present in dementia related to Alzheimer's or Parkinson's disease.
Rivastigmine interacts with target enzymes and forms a covalent binding with them which temporarily deactivates the enzymes. The inhibition of cholinesterase can lead to a delay in the formation of fragments of the protein beta-precursor of amyloid and the formation of amyloid plaques that are characteristic for Alzheimer's disease.
In healthy young men, taking a dose of 3 mg orally reduces the activity of acetylcholinesterase in the cerebrospinal fluid by approximately 40% during the first 1.5 hours. The enzyme activity returns to the initial values at about 9 hours after reaching the maximum inhibition effect. In patients with Alzheimer's disease, the inhibition depends on the dose.
The medication is well-absorbed when taken by mouth. Its bioavailability is around 30-40%. The maximum concentration in the blood is achieved within one hour of intake. The active substance is metabolized by the hydrolysis with the participation of esterases. Then, it is mainly excreted in urine (around 99%) and feces.
According to the studies on animals, the medication doesn’t influence the fetus. However, it is not established whether it penetrates into the breast milk or not. If you expect a baby or breastfeed, you need to consult your doctor before you buy Exelon.
When is Exelon prescribed to be used?
The medication is appointed for the therapy of dementia due Alzheimer’s disease or Parkinson’s disease of mild to moderate stages.
Dementia is an acquired or developed lowering of cognitive functions (thinking, focusing, remembering, etc.), persistent decline in cognitive activity, with the loss, to varying degrees, of previously acquired knowledge and practical skills and the difficulty or inability to acquire new ones.
If you believe that someone from your family suffers from this condition, make sure o consult a specialist before you buy Rivastigmine. Even though we sell all medications without prescriptions we encourage our clients to go to a doctor to find out the precise diagnosis before they order any drugs and start taking them.
When is the use of Rivastigmine contraindicated?
The medication is contraindicated in intolerance of the active ingredients of the pills which is manifested either in moderate to severe adverse reactions or allergic reactions to the pills use, in severe liver dysfunction, and during breastfeeding.
The medication can be used during pregnancy only if the expected benefit is higher than the risks.
The limitations for the use
If a patient who wants to buy Generic Rivastigmine suffers from ulcer of the stomach or duodenum, sick sinus syndrome, conduction disorder (sinoatrial and AV-block), arrhythmias, asthma and COPD (including history), urinary tract obstruction, epilepsy, simultaneous reception of other cholinomimetic agents, or is pregnant, they should render caution when using the drug and necessarily consult a doctor about the safety of the therapy before they start it.
How should Generic Rivastigmine be used?
The treatment must be started under a doctor’s supervision. Preferably, the doctor should be experienced in treating namely dementia associated with Alzheimer’s or Parkinson’s disease. The therapy can be prescribed only to people who have caregivers who can ensure the regular use of the pills.
The pills should be taken twice a day – one dose in the morning and another one in the evening during meals. The pills must be swallowed entirely without chewing.
The initial treatment dose is 1.5 mg two times a day. If the drug is well-tolerated not sooner, in two weeks the dose can be raised to 3 mg taken twice a day. The further rise of the dose to 4.5 and 6 mg taken twice a day is possible only in well-tolerance of the dose and not sooner than with 2-week intervals.
In the occurrence of negative reactions such as nausea, vomiting, pain in the abdomen, loss of appetite or body mass, worsening of extrapyramidal symptoms such as tremor, it is advised to skip one or two doses. If the adverse effects do not fade away, it is advised to lower the dose back to the previous one if it was well-tolerated or suspend the treatment.
If the treatment had been suspended for more than three days, it is needed to resume it with the dose of 3 mg split into two 1.5 mg intakes. Then dose elevation should be made as described above.
The optimal maintenance dose is selected individually and is usually in the range between 3 and 6 mg taken twice a day.
To achieve the maximum effect, it is recommended to take the highest well-tolerated dose. The maximum recommended daily dosage is 12 mg split into two intakes.
The therapy can continue as long as it provides the beneficial effect. A doctor responsible for the patient must regularly assess the effectiveness of the medication. If after three months of the therapy the symptoms of dementia do not diminish, the treatment must be discontinued. Besides, it is needed to revise the reasonability of the therapy if there are no signs of recent improvement of the patient’s condition even if there had been an improvement before.
It is impossible to predict the individual reaction to the therapy with the drug. However, it is statistically proven that the best effect is achieved in people with Parkinson’s with moderately manifested dementia or visual hallucinations.
There are no clinical data on the therapy longer than six months.
Interactions of Generic Rivastigmine with other medicines
Here you can find the most notable interactions but before you order Exelon you should check with your doctor or your caregiver should check with your doctor that you are not using any medicines that also have a potentially negative interaction with this medicine.
The concurrent use of Exelon or its generics with Metoclopramide can increase the risk of extrapyramidal side effects.
Rivastigmine can enhance the cholinergic effects of other cholinomimetic drugs, when used simultaneously with anticholinergic drugs, for instance, oxybutynin, Tolterodine, and others, the antagonism of the action can occur (they interfere with each other’s effects). In general, the simultaneous use of the preparation with drugs that affect cholinergic structures is not recommended.
If the medication is used along with beta-blockers especially cardioselective ones, there is a risk of enhanced heart side effects. Therefore, it is not recommended to take Exelon along with beta-blockers.
What side effects can Generic Exelon cause?
The drug use can cause the onset of such adverse effects as increased fatigue, dizziness, headache, sleepiness, agitation, depression, tremor, nausea, vomiting, diarrhea, pain in the stomach, loss of appetite, heartburn, allergic reactions, increased sweating, and others.
When you order Generic Exelon, you should know that it can increase the production of gastric juice and related side effects can develop.
Some of the side effects that already developed can be eliminated with the skipping of one or several doses of the preparation. If they still persist after the therapy is resumed, it is indicated to lower the dosage back to the maximum one which was well-tolerated.
In case of the occurrence of allergic dermatitis in patients, treatment with Rivastigmine should be discontinued.
Overdose sins and therapy
The symptoms of an overdose are nausea, diarrhea, and vomiting.
The therapy includes the suspending of the treatment for 24 hours and the use of anti-vomit medications and other the symptomatic therapy if needed.
Where can you buy Exelon cheap?
The drug is sold at the regular drugstores but people who want to buy it cheaper should order Rivastigmine from an online med store like ours. Our benefits are cheaper prices because of lower operating expenses and the possibility to sell medicines without Rx. We are able to do so because our office and warehouses are located in the country where these medicines are over-the-counter ones.
Shipping of Exelon
Order the pills without any worries – we ship all products internationally.
Exelon — Frequently Asked Questions
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What is Exelon (Rivastigmine) used for?
Exelon is used to treat mild to moderate dementia associated with Alzheimer's disease and Parkinson's disease, helping to improve memory, awareness, and the ability to perform daily functions. -
How does Exelon work?
Rivastigmine works by inhibiting acetylcholinesterase and butyrylcholinesterase, enzymes that break down acetylcholine in the brain, thereby increasing acetylcholine levels and aiding in the function of nerve cells. -
How is Exelon administered?
Exelon is available in oral (capsules, liquid) and transdermal patch forms. The method of administration depends on the patient's condition, preference, and doctor's recommendation. -
What are the side effects of Exelon?
Common side effects include nausea, vomiting, diarrhea, weight loss, and dizziness. Some patients may also experience headache, abdominal pain, or fatigue. -
Can Exelon cure Alzheimers or Parkinsons disease dementia?
No, Exelon does not cure these conditions but can help manage symptoms and improve quality of life. -
How long does it take for Exelon to work?
Some patients may notice improvements within a few weeks, but it may take several months to achieve the full benefits. -
Is there a preferred time of day to apply the Exelon patch?
The Exelon patch should be applied once daily, at the same time each day, to clean, dry, hairless skin on the back, chest, or upper arm.
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