Generic Coversyl (Perindopril 2 mg) guide:
When should you use the drug?
You can buy Generic Coversyl (Perindopril) and use it as indicated in the instruction unless your doctor gives you other indications. If you have dosage recommendations from your doctor, neglect the instruction and follow your doctor’s prescription.
The conditions for which the drug is used include hypertension including renovascular, congestive heart failure, and prevention of repeated stroke in patients who had a stroke or transient ischemic attack (microinsult), and in stable ischemic heart disease.
How does Coversyl (Perindopril) act?
The medication is an angiotensin-converting enzyme inhibitor. Within the body, it transforms into an active metabolite Perindoprilat which interacts with the zinc atom in the molecule of angiotensin-converting enzyme. It eliminates the blood vessels narrowing effect of angiotensin II in the blood plasma, endothelium of the vascular wall, possibly in cells of renal tubules, lung tissue, heart, adrenal tissue and brain; increases the concentration of bradykinin and vasodilator prostaglandins, reduces the production and release of aldosterone and noradrenaline and the formation of endothelin in the blood vessel walls, increases the activity of the blood plasma renin, circulating and tissue kallikrein-kinin system and the system of prostaglandins.
Coversyl (Perindopril) promotes the recovery of the large arterial vessels elasticity, lowers the pressure in the lung capillaries; in long-term therapy it lowers the severity of the left ventricular and the myocardium hypertrophy and interstitial fibrosis, lowers the heart preload and afterload, i.e. lowers blood pressure in the "lying" and "standing" position, the systemic vascular resistance, filling pressure of the left and right ventricles, increases the minute volume of blood circulation and cardiac index, does not increase the heart rate (in patients with chronic heart failure moderately reduces the heart rate), increases the blood circulation in the muscles and the concentration of high-density lipoproteins, in patients with hyperuricemia reduces the concentration of uric acid.
Coversyl (Perindopril) enhances the renal blood circulation without changing the creatinine clearance, the reduction in the clinical symptoms of congestive heart failure and increases the tolerance towards physical exercise.
After the oral intake of an average dosage, the maximum hypotensive effect is achieved in 4-6 hours and maintains within 24 hours. The stabilization of the blood pressure is observed one month within therapy and is maintained for long period of time.
How should the drug be used?
Before you buy Generic Coversyl (Perindopril), though the drug comes with the instruction, we recommend you to clarify with your doctor what dosage is suitable for you and for how long you should use the medication.
The general instructions say that the starting dosage of the medication is:
- For the treatment of congestive heart failure: 1-2 mg taken once a day. The maintenance dosage is 2-4 mg a day.
- For the treatment of hypertension: 4-8 mg once a day. The maximum daily dosage is 16 mg.
The adjustment for people with impaired kidney function is made based on creatinine clearance.
- For the treatment of coronary artery disease: the starting dosage is 4 mg in a single intake for two weeks. If no adverse reactions occur, the dosage can be then increased to 8 mg daily in a single intake.
Dosages adjustments for other groups of patients
- Elderly patients should start the treatment of hypertension from 4 mg daily taken in a single or two intakes.
- Elderly patients should start the treatment of coronary artery disease from 2 mg in a single intake during the first week of the therapy and then increase it to 4 mg if the drug doesn’t cause any adverse effects. Subsequently, the daily dosage can be increased to 8 mg. daily.
- People with kidney failure with creatinine clearance 30 ml per minute or more should start the treatment with 2 mg daily. The maximum dosage is 8 mg which can be used if the tests show that the drug doesn’t influence the renal function. People with lower creatinine clearance rate should not use the medication.
What are contraindications for Perindopril use?
The medication is contraindicated for people who have history of swelling, for pregnant and breastfeeding women, children, in hypersensitivity to the active substance or other angiotensin-converting enzyme inhibitors, in kidney dysfunction with the creatinine clearance lower than 60 ml per minute.
What adverse reactions can Coversyl (Perindopril) use cause?
The use of the drug can cause hypotension, chest pain, temporary increase in hemoglobin, fatigue, headache, dizziness, mood fluctuations, sleep violation, muscle cramps, dry mouth, indigestion, allergic reactions including rash, itching, swelling, increased levels of creatinine, potassium, urea in the blood, and impotence.
Here are listed the most common adverse reactions that can be caused by the medication. If you have some of these any other reactions, contact or visit your doctor immediately as you may need a dosage adjustment or even withdrawal of the drug to avoid serious damage to your health.
Compatibility with other medications
The risk of hyperkalemia increases when the medication is combined with potassium salt-containing drugs, diuretics that do not wash out potassium, aliskiren and aliskiren-containing preparations, ACE inhibitors, angiotensin II receptors antagonists, immunosuppressants, and others. The combination of aliskiren-containing preparations also in general increases the risk of the development of life-threatening adverse reactions especially in people with impaired kidney function or diabetes.
You should not buy Generic Coversyl (Perindopril) and use it along with Estramustine as the risk of Quincke's edema rises substantially.
In the simultaneous use with the medications based on lithium, the sharp increase of the concentration of the latter in the blood plasma along with the toxic effects can occur.
People who use insulin and other antidiabetic agents should carefully use ACE inhibitors including Generic Coversyl (Perindopril) because the drug can enhance the hypoglycemic effect of these drugs and even the development of hypoglycemia.
Baclofen amplifies the blood pressure lowering effect of the medication and the reduction of the daily dosage of Perindopril can be necessary.
The combined use with diuretics may require temporary withdrawal of diuretics as during the first week of the treatment, Perindopril and diuretics’ combine effects can cause hypotension (blood pressure lowered below the norm).
Here are listed the most important negative reactions that arise from the combination of the mentioned medications. However, before you buy Generic Coversyl (Perindopril), make sure to inform your doctor about all drugs that you take or plan to take while using the blood pressure medication so he or she would advise you a dosage adjustment or another medication compatible with your current preparations.
What should you do in the overdose with Coversyl (Perindopril)?
The symptoms of the overdose include lowered blood pressure, shock, slow heart rate, kidney failure, and others.
Once you realized that you overdosed, you should immediately seek medical assistance and induce vomiting. You should also lie down and keep your legs up. If the adverse effects are severe, a hospitalization and symptomatic treatment are required including hemodialysis and artificial pacemaker use.
Is there a difference between the brand-name drug and the generic?
No, the drugs are identical by the composition and effect. Therefore, there is no need to buy expensive drug.
Where to buy Coversyl (Perindopril)?
At our online pharmacy you can get either the brand-name medication or buy Generic Coversyl (Perindopril) at an affordable price which is significantly lower than at your local pharmacies.
Coversyl (Perindopril) shipping by Rxshop
We will deliver your order to any city or town, including the U.S. We offer standard (cheaper) and express shipping options both of which come with tracking numbers. Find out more about our shipping, returns and refund policies in the respective section of our website or contacting our customer support managers.
Our doctor prescribes Perindopril online for free, and there is no doctor’s consultation fee.
All orders of Perindopril arrive in discrete unmarked parcels. We leave the shipment description blank.