May 22 / 2014

What is better Modafinil or Armodafinil?

Modafinil primarily is a wakefulness-enhancing formulation for narcolepsy. It is available under a variety of names including Provigil, Modalert, and others. All of them are the same medications based on Modafinil if this unpatented name is indicated under the trademark. The popular uses of the medication without prescription are: wakefulness promoting in healthy people, cognitive function enhancing agent, means to help focusing with ADHD, and so on. The medication has a very low addiction potential so it is quite safe to use even for extended periods of time.

Armodafinil can be called an improved version of Modafinil. It is based on the basically the same formula with slight changes that ensure the same effect as of Modafinil but rendered for longer time. Besides, due to the improvements made, the medication can be used in slightly lowered dosages than Modafinil. Armodafinil also has a very low potential for addiction development and therefore is safe to use in narcolepsy and other disorders that require continuous use of the pills.

Comparison of Modafinil and Armodafinil

Here you can see a comparison of key parameters of both drugs which can help you decide what suits you better.

Characteristics

Modafinil

Armodafinil

Class

analeptics; nootropics

Methods of administration

Oral pills

Time of intake

Before noon with or without meals.

Dosage per day

200 mg

150 mg

Legal status

Rx-only

Indications for use

Narcolepsy, shift-work sleep disorder, obstructive sleep apnea

Narcolepsy, shift work sleep disorder, obstructive sleep apnea

Non-prescription uses

Attention deficit hyperactivity disorder, apathy associated with depression, Parkinson’s disease, cognitive functions impairment caused by brain trauma or surgery, chronic fatigue syndrome, opiate-related sleepiness, impaired cognitive functions due to chemotherapy, multiple sclerosis, enhancement of cognitive functions, weight loss aid, jet-lag, and others.

Commercial names

Modalert, Provigil, Modafinil, and others

Nuvigil, Artvigil, and others

Duration of action

Up to 10 hours

Up to 15 hours

Metabolism

Liver

Excreted in

Urine

Principle of action

The principle of Modafinil action isn’t fully understood yet. It is considered that it is due to the release of monoamines, especially catecholamine, norepinephrine and dopamine from synaptic clefts. Besides, Modafinil raises the level in histamine of the hypothalamus which is responsible for inhibition of sleepiness through natural mechanisms.

The principle of Armodafinil action is the same as of Modafinil. It is considered that it is due to the release of monoamines such as catecholamine, norepinephrine and dopamine from synaptic clefts. On top of that, Armodafinil elevates the level of histamine in the hypothalamus which is responsible for inhibition of sleepiness through natural mechanisms.

Possible adverse reactions

Adverse effects are rare and transient. They may include: Headache, anxiety, trouble falling asleep, and nausea. Severe adverse reactions can include allergic reactions such as anaphylaxis, Stevens-Johnson syndrome, or hallucinations.

Adverse effects are quite rare in the use of Armodafinil. They usually fade over a couple of days. Insomnia associated with the medication use can be prevented by the use of the pills in the morning only. The possible adverse reactions include: headache, dryness of the mouth, nausea, lightheadedness, and trouble falling asleep, hallucinations, euphoria, loss of appetite, and anxiety.

Prohibitions for use

Increased sensitivity to the tablets’ components; Pregnancy and lactation; Age under 18 years; Liver cirrhosis. Heart diseases and namely the left ventricular hypertrophy or mitral valve prolapse.

Increased sensitivity to the Armodafinil components; Pregnancy and lactation; Age under 18 years; Liver cirrhosis. Heart diseases and namely the left ventricular hypertrophy or mitral valve prolapse.

Pregnancy category

C (contraindicated, there hadn’t been studies of the drug use in pregnant women).

Overdose symptoms

Possible manifestations of an overdose include excitability, trouble falling asleep, anxiety, irritability, aggressive behavior, confusion, tremor, heart palpitations, sleep disturbances, vomiting, and diarrhea. The treatment is symptomatic.

Precautions for medication use

Modafinil should be taken only in the morning or the first half of the day or it can cause insomnia; The formulation negatively influences the effect of oral birth control so other adequate contraception methods are advised.

Armodafinil should be taken only in the morning or the first half of the day or it can cause insomnia; The formulation negatively influences the effect of oral birth control so other adequate contraception methods are advised.

Interactions

Modafinil is an inducer of a certain liver enzyme which means that the enzyme is more active when the drug is used. Due to this, some of the medications that are metabolized with CYP3A4 enzyme participation can be washed out faster.

Armodafinil, as well as Modafinil, is an inducer of CYP3A4 enzyme which means that the enzyme is more active when the drug is used. Due to this, some of the medications that are metabolized with its participation can be washed out faster.

Number of pills

Modafinil price

Armodafinil price

30 pills

$59.90

$69.90

60 pills

$99.80

$132.90

90 pills

$149.90

$193.90

120 pills

$168.90

$245.90

150 pills

$249.80

N/a

Modafinil and Armodafinil both are perfect medications for narcolepsy and other conditions in which excessive sleepiness is a problem. Besides, since the medications are designed for long-term use, they are safe, do not cause addiction or any harm to the body or mental health. You can buy Armodafinil or Modafinil at our online drugstore at an attractive price and without Rx which makes the purchase even more beneficial.

(Updated at Mar 4 / 2025)

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